GC50366
AMG 18 hydrochloride
Also known as 2-chloro-N-[6-methyl-5-[[3-[2-[[(3S)-piperidin-3-yl]amino]pyrimidin-4-yl]-2-pyridinyl]oxy]naphthalen-1-yl]benzenesulfonamide;hydrochloride
AMG 18 hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5·9 nM
ChemicalCAS2250019-92-0MW637.58FormulaC31H29ClN6O3S·HCl
- CAS number
- 2250019-92-0
- Molecular weight
- 637.58
- Formula
- C31H29ClN6O3S·HCl
- Solubility
- Soluble in DMSO
- InChIKey
- CNWIPRHGMZTPSB-BOXHHOBZSA-N
- Catalogue number
- GC50366
- Brand
- GLPBIO
Computed properties PubChem CID 134160238 · TPSA 127 Ų · H-bond donors 4 · H-bond acceptors 9
- TPSA
- 127 Ų
- H-bond donors
- 4
- H-bond acceptors
- 9
- Rotatable bonds
- 8
- Heavy atoms
- 43
SMILES CC1=C(C2=C(C=C1)C(=CC=C2)NS(=O)(=O)C3=CC=CC=C3Cl)OC4=C(C=CC=N4)C5=NC(=NC=C5)N[C@H]6CCCNC6.Cl
Computed descriptors from PubChem (CID 134160238), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il