GC39624
GNE-618
Also known as N-[[4-[3-(trifluoromethyl)phenyl]sulfonylphenyl]methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM· GNE-618 depletes NAD levels and induces tumor cell death· Anti-tumor activity
ChemicalCAS1362151-42-5MW460.43FormulaC21H15F3N4O3S
- CAS number
- 1362151-42-5
- Molecular weight
- 460.43
- Formula
- C21H15F3N4O3S
- Solubility
- DMSO： 125 mg/mL (271·49 mM)
- InChIKey
- LKBHAGGICJWHQQ-UHFFFAOYSA-N
- Catalogue number
- GC39624
- Brand
- GLPBIO
Computed properties PubChem CID 66613669 · XLogP 3.3 · TPSA 113 Ų · H-bond donors 2
- XLogP
- 3.3
- TPSA
- 113 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Rotatable bonds
- 5
- Heavy atoms
- 32
SMILES C1=CC(=CC(=C1)S(=O)(=O)C2=CC=C(C=C2)CNC(=O)C3=CN=C4C(=C3)C=NN4)C(F)(F)F
Computed descriptors from PubChem (CID 66613669), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il