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Chemical structure of AMG-837 sodium

GC35314

AMG-837 sodium

Also listed as AMG 837 sodium salt

AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents

ChemicalCAS865231-45-4MW460.42FormulaC26H20F3NaO3
CAS number
865231-45-4
Molecular weight
460.42
Formula
C26H20F3NaO3
Solubility
Soluble in DMSO
InChIKey
CRTDAZVPDCRYKT-BOXHHOBZSA-M
Catalogue number
GC35314
Brand
GLPBIO
Computed properties PubChem CID 46854654 · TPSA 49.4 Ų · H-bond donors 0 · H-bond acceptors 6
TPSA
49.4 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
33

SMILES CC#C[C@@H](CC(=O)[O-])C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F.[Na+]

Computed descriptors from PubChem (CID 46854654), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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