GC34355
SEL120-34A monohydrochloride
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4·4 nM and 10·4 nM, respectively, with a Kd of 3 nM for CDK8· SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7· SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726· Has anti-tumor activity
ChemicalMW450.6FormulaC15H19Br2ClN4
- CAS number
- —
- Molecular weight
- 450.6
- Formula
- C15H19Br2ClN4
- Solubility
- DMSO ： 13 mg/mL (28·85 mM)
- Catalogue number
- GC34355
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il