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Chemical structure of SEC inhibitor KL-2

GC38561

SEC inhibitor KL-2

Also known as (Z)-N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-4-hydroxy-2-oxobut-3-enamide

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation· SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1·50 μM

ChemicalCAS900308-51-2MW333.74FormulaC17H13ClFNO3
CAS number
900308-51-2
Molecular weight
333.74
Formula
C17H13ClFNO3
Solubility
Soluble in DMSO
InChIKey
FKGPCOZLGSAHRR-DHDCSXOGSA-N
Catalogue number
GC38561
Brand
GLPBIO
Computed properties PubChem CID 46248669 · XLogP 4.1 · TPSA 66.4 Ų · H-bond donors 2
XLogP
4.1
TPSA
66.4 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
23

SMILES CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)/C=C(/C2=CC=C(C=C2)F)\O

Computed descriptors from PubChem (CID 46248669), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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