GC38063
SEC inhibitor KL-1
Also known as N-(5-chloro-2-methylphenyl)-4-hydroxy-4-(3-methoxyphenyl)-2-oxobut-3-enamide
SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation· SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3·48 μM
- CAS number
- 900308-84-1
- Molecular weight
- 345.78
- Formula
- C18H16ClNO4
- Solubility
- DMSO： 41·67 mg/mL (120·51 mM)
- InChIKey
- ARTVILCEXNCVIN-UHFFFAOYSA-N
- Catalogue number
- GC38063
- Brand
- GLPBIO
Computed properties PubChem CID 75186111 · XLogP 4 · TPSA 75.6 Ų · H-bond donors 2
- XLogP
- 4
- TPSA
- 75.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 24
SMILES CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)C=C(C2=CC(=CC=C2)OC)O
Computed descriptors from PubChem (CID 75186111), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il