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Chemical structure of GNE 220 Hydrochloride

GC34208

GNE 220 Hydrochloride

Also known as 6-methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene;hydrochloride

GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM

ChemicalCAS2448286-21-1MW474.99FormulaC25H27ClN8
CAS number
2448286-21-1
Molecular weight
474.99
Formula
C25H27ClN8
Solubility
DMSO ： 5·4 mg/mL (11·37 mM)
InChIKey
VBVBAEHNBOTZQV-UHFFFAOYSA-N
Catalogue number
GC34208
Brand
GLPBIO
Computed properties PubChem CID 134828260 · TPSA 78.8 Ų · H-bond donors 2 · H-bond acceptors 6
TPSA
78.8 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
34

SMILES CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C.Cl

Computed descriptors from PubChem (CID 134828260), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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