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Chemical structure of GNE-6468

GC33882

GNE-6468

Also known as 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid

GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell

ChemicalCAS1677668-27-7MW433.84FormulaC23H16ClN3O4
CAS number
1677668-27-7
Molecular weight
433.84
Formula
C23H16ClN3O4
Solubility
DMSO： 5 mg/mL (11·52 mM)
InChIKey
GIYKJPISDNWSJD-UHFFFAOYSA-N
Catalogue number
GC33882
Brand
GLPBIO
Computed properties PubChem CID 117964975 · XLogP 5.7 · TPSA 105 Ų · H-bond donors 2
XLogP
5.7
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
31

SMILES C1CC1C2=C(C(=CC=C2)Cl)C(=O)C3=NC(=C4N3C=CC=N4)C5=CC(=C(C=C5)C(=O)O)O

Computed descriptors from PubChem (CID 117964975), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.