Loading...
Chemical structure of GNE-272

GC32747

GNE-272

Also known as 1-[3-[2-fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone

GNE-272 is a potent and selective inhibitor of cyclic AMP response element binding protein (CBP), an inhibitor of E1A binding protein p300 (EP300), with IC50 values of 0·02 and 0·03μM, respectively· It is also an in vivo probe of CBP/EP300 bromodomains

ChemicalCAS1936428-93-1MW424.47FormulaC22H25FN6O2
CAS number
1936428-93-1
Molecular weight
424.47
Formula
C22H25FN6O2
Solubility
DMSO ： ≥ 150 mg/mL (353·38 mM)
InChIKey
NKOJNOBJGYTLLZ-KRWDZBQOSA-N
Catalogue number
GC32747
Brand
GLPBIO
Computed properties PubChem CID 121372887 · XLogP 1.5 · TPSA 77.2 Ų · H-bond donors 1
XLogP
1.5
TPSA
77.2 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
31

SMILES CC(=O)N1CCC2=C(C1)C(=NN2[C@H]3CCOC3)NC4=C(C=C(C=C4)C5=CN(N=C5)C)F

Computed descriptors from PubChem (CID 121372887), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.