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Chemical structure of GNE-3511

GC19173

GNE-3511

Also known as 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]-2-pyridinyl]amino]pyridine-4-carbonitrile

GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0·5 nM

ChemicalCAS1496581-76-0MW440.49FormulaC23H26F2N6O
CAS number
1496581-76-0
Molecular weight
440.49
Formula
C23H26F2N6O
Solubility
DMSO : ≥ 32 mg/mL (72·65 mM)
InChIKey
RHFIAUKMKYHHFA-UHFFFAOYSA-N
Catalogue number
GC19173
Brand
GLPBIO
Computed properties PubChem CID 72547959 · XLogP 3.2 · TPSA 77.3 Ų · H-bond donors 1
XLogP
3.2
TPSA
77.3 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
32

SMILES C1CN(CCC1C2=CC(=NC(=C2)N3CCC(C3)(F)F)NC4=NC=CC(=C4)C#N)C5COC5

Computed descriptors from PubChem (CID 72547959), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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