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Chemical structure of GNE-495

GC18257

GNE-495

Also known as 8-amino-N-[1-(cyclopropanecarbonyl)azetidin-3-yl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide

GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3·7 nM)

ChemicalCAS1449277-10-4MW405.4FormulaC22H20FN5O2
CAS number
1449277-10-4
Molecular weight
405.4
Formula
C22H20FN5O2
Solubility
DMF： 5 mg/ml,DMSO： 5 mg/ml,DMSO：PBS (pH 7·2) (1：7)： 0·125 mg/ml,Ethanol： slightly soluble
InChIKey
FYXCIBJXJYBWPX-UHFFFAOYSA-N
Catalogue number
GC18257
Brand
GLPBIO
Computed properties PubChem CID 89730041 · XLogP 1.6 · TPSA 101 Ų · H-bond donors 2
XLogP
1.6
TPSA
101 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
30

SMILES C1CC1C(=O)N2CC(C2)NC(=O)C3=CN=C(C4=C3C=CC(=N4)C5=CC(=CC=C5)F)N

Computed descriptors from PubChem (CID 89730041), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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