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Chemical structure of EPZ-6438

GC14062

EPZ-6438

Also known as N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide

EPZ-6438 is a potent and bio-available inhibitor of EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2) catalyzing the methylation of lysine 27 of histone H3 (H3K27), that inhibits the activity of human PRC2-containing wild-type EZH2 with a value of inhibition constant Ki of 2·5 nM

ChemicalCAS1403254-99-8MW572.74FormulaC34H44N4O4
CAS number
1403254-99-8
Molecular weight
572.74
Formula
C34H44N4O4
Solubility
≥ 28·637mg/mL in DMSO
InChIKey
NSQSAUGJQHDYNO-UHFFFAOYSA-N
Catalogue number
GC14062
Brand
GLPBIO
Computed properties PubChem CID 66558664 · XLogP 4.2 · TPSA 83.1 Ų · H-bond donors 2
XLogP
4.2
TPSA
83.1 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
42

SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5

Computed descriptors from PubChem (CID 66558664), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.