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Chemical structure of PROTAC IRAK4 degrader-3

GF04051

PROTAC IRAK4 degrader-3

Also known as 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-4-[3-[3-[5-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]pyrimidin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]prop-1-ynyl]-7-methoxyisoquinoline-6-carboxamide

PROTAC IRAK4 degrader-3 (catalogue number GF04051) is a research-grade chemical available from LABO Scientific in Israel, CAS registry number 2374122-43-5. Molecular formula C57H68FN11O8S, molecular weight 1086.28. IUPAC name: 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-4-[3-[3-[5-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]pyrimidin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]prop-1-ynyl]-7-methoxyisoquinoline-6-carboxamide. Supplied in 2 pack sizes, from 1mg at ₪893.28 to 5mg at ₪2,626.82; the final price is confirmed on your quote, and the lot certificate of analysis and safety data sheet are emailed with your order confirmation.

ChemicalCAS2374122-43-5MW1086.28FormulaC57H68FN11O8S
CAS number
2374122-43-5
Molecular weight
1086.28
Formula
C57H68FN11O8S
Solubility
DMSO ： 100 mg/mL (92·06 mM; Need ultrasonic)
InChIKey
VCCDOPPWOSIMCD-HCDYCOHBSA-N
Catalogue number
GF04051
Brand
GLPBIO
Computed properties PubChem CID 162642666 · XLogP 5.8 · TPSA 276 Ų · H-bond donors 5
XLogP
5.8
TPSA
276 Ų
H-bond donors
5
H-bond acceptors
16
Rotatable bonds
17
Heavy atoms
78

SMILES CC[C@H]1[C@H](NC(=O)[C@H]1F)COC2=NC=C(C3=CC(=C(C=C32)OC)C(=O)N)C#CCN4CCC5(CC4)CCN(CC5)C6=NC=C(C=N6)C(=O)N[C@@H](C(=O)N7C[C@H](C[C@@H]7C(=O)NCC8=CC=C(C=C8)C9=C(N=CS9)C)O)C(C)(C)C

Computed descriptors from PubChem (CID 162642666), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.