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Chemical structure of PROTAC ER Degrader-3

GC34734

PROTAC ER Degrader-3

Also known as tert-butyl N-[(2S)-1-[[(3S,4S)-7-cyano-5-[4-[2-[2-[2-[2-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenoxy]ethyl-methylamino]-2-oxoethoxy]ethoxy]ethylcarbamoyl]benzoyl]-1-[(2-methoxynaphthalen-1-yl)methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]amino]-1-oxopropan-2-yl]-N-methylcarbamate

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC· PAC, consists the ADCs linker and PROTACs, conjugated to an antibody· PAC extracts from patent WO2017201449A1, compound LP2· PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)

ChemicalCAS2158322-29-1MW1220.41FormulaC71H77N7O12
CAS number
2158322-29-1
Molecular weight
1220.41
Formula
C71H77N7O12
Solubility
Soluble in DMSO
InChIKey
ZBSUUCSLUPVKFV-OFHFNDNJSA-N
Catalogue number
GC34734
Brand
GLPBIO
Computed properties PubChem CID 138454782 · XLogP 10.7 · TPSA 230 Ų · H-bond donors 3
XLogP
10.7
TPSA
230 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
26
Heavy atoms
90

SMILES CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C(=O)COCCOCCNC(=O)C3=CC=C(C=C3)C(=O)N4[C@H]([C@@H](C(=O)N(C5=C4C=C(C=C5)C#N)CC6=C(C=CC7=CC=CC=C76)OC)NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C)/C8=CC=CC=C8

Computed descriptors from PubChem (CID 138454782), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.