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Chemical structure of PROTAC IRAK4 degrader-1

GC62197

PROTAC IRAK4 degrader-1

Also known as 2-[2-(cyclopropylmethylamino)-4-pyridinyl]-N-[1-[4-[3-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]methyl]imidazol-1-yl]propylcarbamoyl]phenyl]-3-(trifluoromethyl)pyrazol-4-yl]-1,3-oxazole-4-carboxamide

PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0·01, 0·1, and 1 μM in OCI-LY-10 cells, respectively

ChemicalCAS2360533-90-8MW904.85FormulaC44H39F3N12O7
CAS number
2360533-90-8
Molecular weight
904.85
Formula
C44H39F3N12O7
InChIKey
YXSXFMHKDNIZFS-UHFFFAOYSA-N
Catalogue number
GC62197
Brand
GLPBIO
Computed properties PubChem CID 138727281 · XLogP 3.7 · TPSA 240 Ų · H-bond donors 5
XLogP
3.7
TPSA
240 Ų
H-bond donors
5
H-bond acceptors
16
Rotatable bonds
16
Heavy atoms
66

SMILES C1CC1CNC2=NC=CC(=C2)C3=NC(=CO3)C(=O)NC4=CN(N=C4C(F)(F)F)C5=CC=C(C=C5)C(=O)NCCCN6C=C(N=C6)CNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 138727281), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.