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Chemical structure of PROTAC IRAK4 degrader-3

GC75192

PROTAC IRAK4 degrader-3

Also known as 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-4-[3-[3-[5-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]pyrimidin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]prop-1-ynyl]-7-methoxyisoquinoline-6-carboxamide

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau

ChemicalCAS2374122-43-5MW1086.28FormulaC57H68FN11O8S
CAS number
2374122-43-5
Molecular weight
1086.28
Formula
C57H68FN11O8S
Solubility
DMSO： 100 mg/mL (92·06 mM; Need ultrasonic)
InChIKey
VCCDOPPWOSIMCD-HCDYCOHBSA-N
Catalogue number
GC75192
Brand
GLPBIO
Computed properties PubChem CID 162642666 · XLogP 5.8 · TPSA 276 Ų · H-bond donors 5
XLogP
5.8
TPSA
276 Ų
H-bond donors
5
H-bond acceptors
16
Rotatable bonds
17
Heavy atoms
78

SMILES CC[C@H]1[C@H](NC(=O)[C@H]1F)COC2=NC=C(C3=CC(=C(C=C32)OC)C(=O)N)C#CCN4CCC5(CC4)CCN(CC5)C6=NC=C(C=N6)C(=O)N[C@@H](C(=O)N7C[C@H](C[C@@H]7C(=O)NCC8=CC=C(C=C8)C9=C(N=CS9)C)O)C(C)(C)C

Computed descriptors from PubChem (CID 162642666), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.