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Chemical structure of NRX-0492

GC73434

NRX-0492

Also known as 3-[4-[1-[[(3S)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl]piperidin-4-yl]anilino]-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide

NRX-0492 is an orally active and potent degrader of BTK

ChemicalCAS2416130-57-7MW817.94FormulaC43H51N11O6
CAS number
2416130-57-7
Molecular weight
817.94
Formula
C43H51N11O6
Solubility
DMSO ： 200 mg/mL (244·52 mM; Need ultrasonic)
InChIKey
WFDYOAWNEOGIPM-NJZOVTIDSA-N
Catalogue number
GC73434
Brand
GLPBIO
Computed properties PubChem CID 146559024 · XLogP 2.7 · TPSA 198 Ų · H-bond donors 3
XLogP
2.7
TPSA
198 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
10
Heavy atoms
60

SMILES CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(=N3)NC4=CC=C(C=C4)C5CCN(CC5)C[C@@H]6CCN(C6)C7=CC8=C(C=C7)C(=O)N(C8=O)C9CCC(=O)NC9=O)C(=O)N

Computed descriptors from PubChem (CID 146559024), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.