GC65919
NRX-252114
Also known as 2-[4-(2,6-dichlorophenyl)sulfanyl-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]-1,3-dihydroisoindole-4-carbonitrile
NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP· NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6·5 nM and a Kd of 0·4 nM· NRX-252114 induces mutant β-catenin degradation
ChemicalCAS2763260-39-3MW510.32FormulaC22H12Cl2F3N3O2S
- CAS number
- 2763260-39-3
- Molecular weight
- 510.32
- Formula
- C22H12Cl2F3N3O2S
- InChIKey
- BMQXGPBUQGPLOV-UHFFFAOYSA-N
- Catalogue number
- GC65919
- Brand
- GLPBIO
Computed properties PubChem CID 162640509 · XLogP 4.6 · TPSA 98.5 Ų · H-bond donors 1
- XLogP
- 4.6
- TPSA
- 98.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 33
SMILES C1C2=C(CN1C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)C(=CC=C2)C#N
Computed descriptors from PubChem (CID 162640509), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il