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Chemical structure of NRX-2663

GC64832

NRX-2663

Also known as 3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP· NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22·9 ?M and a Kd of 54·8 nM

ChemicalCAS2763260-34-8MW418.32FormulaC20H13F3N2O5
CAS number
2763260-34-8
Molecular weight
418.32
Formula
C20H13F3N2O5
InChIKey
QMARDTCIJVODCK-UHFFFAOYSA-N
Catalogue number
GC64832
Brand
GLPBIO
Computed properties PubChem CID 137628321 · XLogP 2.9 · TPSA 105 Ų · H-bond donors 3
XLogP
2.9
TPSA
105 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
30

SMILES C1=CC=C(C=C1)OC2=C(C(=O)NC(=C2)C(F)(F)F)C(=O)NC3=CC=CC(=C3)C(=O)O

Computed descriptors from PubChem (CID 137628321), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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