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Chemical structure of ARD-2051

GC73277

ARD-2051

Also known as 2-chloro-4-[(3S)-8-[4-[4-[1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]azetidin-3-yl]piperazine-1-carbonyl]phenyl]-3-methyl-2,8-diazaspiro[4.5]decan-2-yl]benzonitrile

ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader

ChemicalCAS2632305-17-8MW789.32FormulaC43H45ClN8O5
CAS number
2632305-17-8
Molecular weight
789.32
Formula
C43H45ClN8O5
Solubility
DMSO ： 25 mg/mL (31·67 mM; Need ultrasonic)
InChIKey
WBMJNGGUHCHFHY-YTCZSSRZSA-N
Catalogue number
GC73277
Brand
GLPBIO
Computed properties PubChem CID 156180835 · XLogP 4.5 · TPSA 141 Ų · H-bond donors 1
XLogP
4.5
TPSA
141 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
57

SMILES C[C@H]1CC2(CCN(CC2)C3=CC=C(C=C3)C(=O)N4CCN(CC4)C5CN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)CN1C9=CC(=C(C=C9)C#N)Cl

Computed descriptors from PubChem (CID 156180835), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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