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Chemical structure of ARD-2128

GC63492

ARD-2128

Also known as N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperidin-4-yl]methyl]piperazin-1-yl]benzamide

ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader· ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity· ARD-2128 has the potential for the research of the prostate cancer

ChemicalCAS2222111-87-5MW820.37FormulaC45H50ClN7O6
CAS number
2222111-87-5
Molecular weight
820.37
Formula
C45H50ClN7O6
InChIKey
BWDWHHAZFQBJQL-UHFFFAOYSA-N
Catalogue number
GC63492
Brand
GLPBIO
Computed properties PubChem CID 140861143 · XLogP 6.2 · TPSA 155 Ų · H-bond donors 2
XLogP
6.2
TPSA
155 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
9
Heavy atoms
59

SMILES CC1(C(C(C1OC2=CC(=C(C=C2)C#N)Cl)(C)C)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5CCN(CC5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C

Computed descriptors from PubChem (CID 140861143), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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