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Chemical structure of PF-07054894

GC73182

PF-07054894

Also known as 4-[[2-[[(R)-(1,4-dimethylpyrazol-3-yl)-(1-methylcyclopentyl)methyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-3-hydroxy-N,N-dimethylpyridine-2-carboxamide

PF-07054894 is an orally active and potent C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) antagonist that blocks CCR6-mediated chemotaxis with an IC50 value of 5·7 nM in vitro

ChemicalCAS2413693-96-4MW466.53FormulaC24H30N6O4
CAS number
2413693-96-4
Molecular weight
466.53
Formula
C24H30N6O4
Solubility
DMSO ： 100 mg/mL (214·35 mM; Need ultrasonic)
InChIKey
WZBSYWCLIMRAHO-QFIPXVFZSA-N
Catalogue number
GC73182
Brand
GLPBIO
Computed properties PubChem CID 146444831 · XLogP 2.9 · TPSA 129 Ų · H-bond donors 3
XLogP
2.9
TPSA
129 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
34

SMILES CC1=CN(N=C1[C@@H](C2(CCCC2)C)NC3=C(C(=O)C3=O)NC4=C(C(=NC=C4)C(=O)N(C)C)O)C

Computed descriptors from PubChem (CID 146444831), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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