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Chemical structure of PF-06928215

GC34712

PF-06928215

Also known as cis-(1R,2S)-2-[(7-oxo-5-phenyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4·9 μΜ

ChemicalCAS2378173-15-8MW380.4FormulaC20H20N4O4
CAS number
2378173-15-8
Molecular weight
380.4
Formula
C20H20N4O4
Solubility
DMSO : 33·33 mg/mL (87·62 mM)
InChIKey
WGQGCLHXUPGUSZ-HIFRSBDPSA-N
Catalogue number
GC34712
Brand
GLPBIO
Computed properties PubChem CID 137300622 · XLogP 2.3 · TPSA 111 Ų · H-bond donors 3
XLogP
2.3
TPSA
111 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
28

SMILES C1CC[C@@H]([C@@H](C1)C(=O)O)NC(=O)C2=CNN3C2=NC(=CC3=O)C4=CC=CC=C4

Computed descriptors from PubChem (CID 137300622), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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