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Chemical structure of MS9449

GC73143

MS9449

Also known as (2S,4R)-N-[(1S)-3-[[11-[4-[3-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypropyl]piperazin-1-yl]-11-oxoundecyl]amino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxopropyl]-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidine-2-carboxamide

MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively

ChemicalCAS2772612-96-9MW1151.82FormulaC60H76ClFN10O8S
CAS number
2772612-96-9
Molecular weight
1151.82
Formula
C60H76ClFN10O8S
Solubility
DMSO ： 200 mg/mL (173·64 mM; Need ultrasonic)
InChIKey
VDUPETHSNLCFNB-HHHFUCLFSA-N
Catalogue number
GC73143
Brand
GLPBIO
Computed properties PubChem CID 164517155 · XLogP 9.6 · TPSA 246 Ų · H-bond donors 4
XLogP
9.6
TPSA
246 Ų
H-bond donors
4
H-bond acceptors
16
Rotatable bonds
28
Heavy atoms
81

SMILES CC1=NOC(=C1)[C@@H](C(C)C)C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@@H](CC(=O)NCCCCCCCCCCC(=O)N3CCN(CC3)CCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)C7=CC=C(C=C7)C8=C(N=CS8)C)O

Computed descriptors from PubChem (CID 164517155), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.