GC69506
MS9427 TFA
MS9427 TFA is an effective PROTAC EGFR degrader, with Kd values of 7·1 nM and 4·3 nM for wild-type EGFR and mutant EGFR L858R, respectively· MS9427 TFA selectively degrades mutant variants through the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathway, but not WT EGFR· MS9427 TFA strongly inhibits NSCLC cell proliferation and can be used in cancer research
ChemicalMW1107.5FormulaC50H59ClF4N8O14
- CAS number
- —
- Molecular weight
- 1107.5
- Formula
- C50H59ClF4N8O14
- Catalogue number
- GC69506
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il