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Chemical structure of MS9427

GC69505

MS9427

Also known as 5-[2-[2-[2-[2-[2-[3-[4-[3-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypropyl]piperazin-1-yl]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

MS9427 is an effective PROTAC EGFR degrader, with Kd values of 7·1 nM and 4·3 nM for wild-type EGFR and mutant EGFR L858R, respectively· MS9427 selectively degrades mutant variants through the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathway, but does not degrade WT EGFR· MS9427 has a strong inhibitory effect on NSCLC cell proliferation and can be used in cancer research

ChemicalCAS2772613-37-1MW993.47FormulaC48H58ClFN8O12
CAS number
2772613-37-1
Molecular weight
993.47
Formula
C48H58ClFN8O12
Solubility
DMSO ： 70 mg/mL (70·46 mM; Need ultrasonic)
InChIKey
DJJBJKUHJYCNMD-UHFFFAOYSA-N
Catalogue number
GC69505
Brand
GLPBIO
Computed properties PubChem CID 164517154 · XLogP 2.8 · TPSA 222 Ų · H-bond donors 3
XLogP
2.8
TPSA
222 Ų
H-bond donors
3
H-bond acceptors
18
Rotatable bonds
28
Heavy atoms
70

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCN(CC4)C(=O)CCOCCOCCOCCOCCOCCNC5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O

Computed descriptors from PubChem (CID 164517154), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.