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Chemical structure of NX-5948

GC71231

NX-5948

Also known as 3-[4-[1-[[1-[6-[[(3S)-2,6-dioxopiperidin-3-yl]carbamoyl]-3-pyridinyl]piperidin-4-yl]methyl]piperidin-4-yl]anilino]-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide

NX-5948 is an orally active proteolytic targeting chimera (PROTAC) that is a Bruton's tyrosine kinase (BTK) degrader

ChemicalCAS2649400-34-8MW806.96FormulaC42H54N12O5
CAS number
2649400-34-8
Molecular weight
806.96
Formula
C42H54N12O5
Solubility
DMSO ： 50 mg/mL (61·96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
HPTPDBYCFHFWJG-CWTKIQHKSA-N
Catalogue number
GC71231
Brand
GLPBIO
Computed properties PubChem CID 156464216 · XLogP 2.6 · TPSA 202 Ų · H-bond donors 4
XLogP
2.6
TPSA
202 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
11
Heavy atoms
59

SMILES CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(=N3)NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(CC6)C7=CN=C(C=C7)C(=O)N[C@H]8CCC(=O)NC8=O)C(=O)N

Computed descriptors from PubChem (CID 156464216), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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