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Chemical structure of NX-2127

GC69600

NX-2127

Also known as 3-[4-[1-[[(3S)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl]piperidin-4-yl]anilino]-5-piperidin-1-ylpyrazine-2-carboxamide

NX-2127 is an orally effective BTK inhibitor that can induce the degradation of mutated BTKC481S in cells· NX-2127 inhibits the proliferation of TMD8 cells with the BTKC481S mutation more effectively than Ibrutinib· NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3), corresponding to concentrations of 25 nM and 54 nM, respectively· NX-2127 stimulates T cell activation and increases IL-2 production in primary human T cells

ChemicalCAS2416131-46-7MW719.83FormulaC39H45N9O5
CAS number
2416131-46-7
Molecular weight
719.83
Formula
C39H45N9O5
Solubility
DMSO ： 100 mg/mL (138·92 mM; Need ultrasonic)
InChIKey
XLWJWCMQMBVNSG-ACXKHFGCSA-N
Catalogue number
GC69600
Brand
GLPBIO
Computed properties PubChem CID 146559796 · XLogP 3.7 · TPSA 174 Ų · H-bond donors 3
XLogP
3.7
TPSA
174 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
53

SMILES C1CCN(CC1)C2=CN=C(C(=N2)NC3=CC=C(C=C3)C4CCN(CC4)C[C@@H]5CCN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C(=O)N

Computed descriptors from PubChem (CID 146559796), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.