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Chemical structure of NXT629

GC32933

NXT629

Also known as N-[6-[4-[3-[1-[(4-tert-butylphenyl)methyl]-4-ethyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenyl]-3-pyridinyl]benzenesulfonamide

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6·0, 15, 15·2, 32·5 and >100 μM, respectively· NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models

ChemicalCAS1454925-59-7MW609.78FormulaC35H39N5O3S
CAS number
1454925-59-7
Molecular weight
609.78
Formula
C35H39N5O3S
Solubility
DMSO ： 125 mg/mL (204·99 mM)
InChIKey
IRSFLNXJVJKMDT-UHFFFAOYSA-N
Catalogue number
GC32933
Brand
GLPBIO
Computed properties PubChem CID 71721539 · XLogP 6.5 · TPSA 103 Ų · H-bond donors 1
XLogP
6.5
TPSA
103 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
12
Heavy atoms
44

SMILES CCN1C(=NN(C1=O)CC2=CC=C(C=C2)C(C)(C)C)CCCC3=CC=C(C=C3)C4=NC=C(C=C4)NS(=O)(=O)C5=CC=CC=C5

Computed descriptors from PubChem (CID 71721539), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.