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Chemical structure of PF-06815345 hydrochloride

GC70347

PF-06815345 hydrochloride

Also known as [(1S)-1-[5-[4-[4-[(3-chloro-2-pyridinyl)-[(3R)-piperidin-3-yl]carbamoyl]-2-fluorophenyl]-1-methylpyrazol-5-yl]tetrazol-1-yl]ethyl] ethyl carbonate;hydrochloride

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13·4 μM

ChemicalCAS2334434-49-8MW634.49FormulaC27H30Cl2FN9O4
CAS number
2334434-49-8
Molecular weight
634.49
Formula
C27H30Cl2FN9O4
Solubility
DMSO ： 50 mg/mL (78·80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
RFEUFHPTEFEGDQ-KUGOCAJQSA-N
Catalogue number
GC70347
Brand
GLPBIO
Computed properties PubChem CID 168006835 · TPSA 142 Ų · H-bond donors 2 · H-bond acceptors 11
TPSA
142 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
10
Heavy atoms
43

SMILES CCOC(=O)O[C@@H](C)N1C(=NN=N1)C2=C(C=NN2C)C3=C(C=C(C=C3)C(=O)N([C@@H]4CCCNC4)C5=C(C=CC=N5)Cl)F.Cl

Computed descriptors from PubChem (CID 168006835), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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