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Chemical structure of PF-06843195

GC62556

PF-06843195

Also known as 2,2-difluoroethyl (3S)-3-[[6-(2-aminopyrimidin-5-yl)-5-fluoro-2-morpholin-4-ylpyrimidin-4-yl]amino]-3-(hydroxymethyl)pyrrolidine-1-carboxylate

PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts· The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0·018 nM and 0·28 nM, respectively· PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy

ChemicalCAS2067281-51-8MW498.46FormulaC20H25F3N8O4
CAS number
2067281-51-8
Molecular weight
498.46
Formula
C20H25F3N8O4
InChIKey
RTOREZYNLPQUKM-FQEVSTJZSA-N
Catalogue number
GC62556
Brand
GLPBIO
Computed properties PubChem CID 124193915 · XLogP 0.4 · TPSA 152 Ų · H-bond donors 3
XLogP
0.4
TPSA
152 Ų
H-bond donors
3
H-bond acceptors
14
Rotatable bonds
8
Heavy atoms
35

SMILES C1CN(C[C@@]1(CO)NC2=NC(=NC(=C2F)C3=CN=C(N=C3)N)N4CCOCC4)C(=O)OCC(F)F

Computed descriptors from PubChem (CID 124193915), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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