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Chemical structure of PF-06821497

GC26668

PF-06821497

Also known as 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one

PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0·1 nM against mutant Y641N EZH2

ChemicalCAS1844849-10-0MW467.34FormulaC22H24Cl2N2O5
CAS number
1844849-10-0
Molecular weight
467.34
Formula
C22H24Cl2N2O5
Solubility
DMSO ： 16·67 mg/mL (35·67 mM; ultrasonic and warming and heat to 60°C)
InChIKey
RXCVUHMIWHRLDF-HXUWFJFHSA-N
Catalogue number
GC26668
Brand
GLPBIO
Computed properties PubChem CID 118572065 · XLogP 2.1 · TPSA 77.1 Ų · H-bond donors 1
XLogP
2.1
TPSA
77.1 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
31

SMILES CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)[C@@H](C4COC4)OC)Cl)OC

Computed descriptors from PubChem (CID 118572065), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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