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Chemical structure of TREM2 agonist-2

GC70058

TREM2 agonist-2

Also known as 5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-2-(1-methylpyrazol-4-yl)oxan-4-yl]pyrido[3,4-b]pyrazine

TREM2 agonist-2 is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50＜0·05μM)

ChemicalCAS2738485-98-6MW451.92FormulaC24H23ClFN5O
CAS number
2738485-98-6
Molecular weight
451.92
Formula
C24H23ClFN5O
InChIKey
DGBQOJDFECEEKU-OYHNWAKOSA-N
Catalogue number
GC70058
Brand
GLPBIO
Computed properties PubChem CID 165412595 · XLogP 3.6 · TPSA 65.7 Ų · H-bond donors 0
XLogP
3.6
TPSA
65.7 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
32

SMILES CC1=NC2=CC(=NC(=C2N=C1C)C3=C(C=C(C=C3)Cl)F)[C@H]4CCO[C@H](C4)C5=CN(N=C5)C

Computed descriptors from PubChem (CID 165412595), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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