Loading...
Chemical structure of TRPV4 agonist-1 free base

GC63244

TRPV4 agonist-1 free base

Also known as 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one

TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay

ChemicalCAS2314467-59-7MW448.46FormulaC25H22F2N4O2
CAS number
2314467-59-7
Molecular weight
448.46
Formula
C25H22F2N4O2
Solubility
DMSO ： 83·33 mg/mL (185·81 mM; Need ultrasonic)
InChIKey
NUGPMKZYSBKNPU-UHFFFAOYSA-N
Catalogue number
GC63244
Brand
GLPBIO
Computed properties PubChem CID 137628676 · XLogP 4 · TPSA 48.4 Ų · H-bond donors 0
XLogP
4
TPSA
48.4 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
33

SMILES CN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F

Computed descriptors from PubChem (CID 137628676), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.