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Chemical structure of TRPV4 agonist-1

GC65536

TRPV4 agonist-1

Also known as 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one;hydrochloride

TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay

ChemicalCAS2314467-60-0MW484.93FormulaC25H23ClF2N4O2
CAS number
2314467-60-0
Molecular weight
484.93
Formula
C25H23ClF2N4O2
Solubility
DMSO ： ≥50mg/mL
InChIKey
ONVDBGZQVBEFIO-UHFFFAOYSA-N
Catalogue number
GC65536
Brand
GLPBIO
Computed properties PubChem CID 137628675 · TPSA 48.4 Ų · H-bond donors 1 · H-bond acceptors 6
TPSA
48.4 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
34

SMILES CN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F.Cl

Computed descriptors from PubChem (CID 137628675), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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