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Chemical structure of TREM-1 inhibitory peptide GF9

GC72101

TREM-1 inhibitory peptide GF9

Also known as (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoic acid

TREM-1 inhibitory peptide GF9 (Human TREM-1(213-221)) is a ligand‐independent TREM‐1 inhibitory nonapeptide GF9 that can blunt excessive inflammation caused by rheumatoid arthritis (RA)

ChemicalCAS1289375-12-7MW997.19FormulaC49H76N10O12
CAS number
1289375-12-7
Molecular weight
997.19
Formula
C49H76N10O12
Solubility
DMSO ： 1·92 mg/mL (1·93 mM; ultrasonic and adjust pH to 7 with CH3COOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
MNVMEIMCBGNQIJ-YEFFYANISA-N
Catalogue number
GC72101
Brand
GLPBIO
Computed properties PubChem CID 169494428 · XLogP -1 · TPSA 363 Ų · H-bond donors 13
XLogP
-1
TPSA
363 Ų
H-bond donors
13
H-bond acceptors
14
Rotatable bonds
32
Heavy atoms
71

SMILES CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CN

Computed descriptors from PubChem (CID 169494428), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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