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Chemical structure of ML375

GC69476

ML375

Also known as (9bS)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one

ML375 (VU0483253) is an effective, highly selective, blood-brain barrier penetrant and orally active M5 mAChR negative allosteric modulator (NAM), with IC50 values of 300 nM and 790 nM for human and rat M5, respectively· ML375 has no activity on human and rat M1-M4

ChemicalCAS1488362-55-5MW424.83FormulaC23H15ClF2N2O2
CAS number
1488362-55-5
Molecular weight
424.83
Formula
C23H15ClF2N2O2
Solubility
DMSO ： 40 mg/mL (94·16 mM; Need ultrasonic and warming)
InChIKey
GXBAKXRLQAPKEE-QHCPKHFHSA-N
Catalogue number
GC69476
Brand
GLPBIO
Computed properties PubChem CID 71598521 · XLogP 4.3 · TPSA 40.6 Ų · H-bond donors 0
XLogP
4.3
TPSA
40.6 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
30

SMILES C1CN([C@]2(N1C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl)C(=O)C5=CC(=C(C=C5)F)F

Computed descriptors from PubChem (CID 71598521), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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