Loading...
Chemical structure of ML380

GC61802

ML380

Also known as N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide

ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC50s of 190 and 610 nM for human and rat M5, respectively

ChemicalCAS1627138-52-6MW494.53FormulaC23H25F3N4O3S
CAS number
1627138-52-6
Molecular weight
494.53
Formula
C23H25F3N4O3S
Solubility
DMSO： 100 mg/mL (202·21 mM)
InChIKey
FJPQEOQGIZSLES-UHFFFAOYSA-N
Catalogue number
GC61802
Brand
GLPBIO
Computed properties PubChem CID 71737672 · XLogP 3.4 · TPSA 94.8 Ų · H-bond donors 1
XLogP
3.4
TPSA
94.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
34

SMILES CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4

Computed descriptors from PubChem (CID 71737672), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.