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Chemical structure of ML381

GC70225

ML381

Also known as 5-[(3-acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide

ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM)

ChemicalCAS1623481-80-0MW379.41FormulaC21H21N3O4
CAS number
1623481-80-0
Molecular weight
379.41
Formula
C21H21N3O4
Solubility
DMSO ： 100 mg/mL (263·57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
JMYDHMCYZKRDPD-AWEZNQCLSA-N
Catalogue number
GC70225
Brand
GLPBIO
Computed properties PubChem CID 42519285 · XLogP 2.2 · TPSA 85.5 Ų · H-bond donors 0
XLogP
2.2
TPSA
85.5 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
28

SMILES C[C@@H](C1=CC=CC=N1)N(C)C(=O)C2=NOC(=C2)COC3=CC=CC(=C3)C(=O)C

Computed descriptors from PubChem (CID 42519285), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.