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Chemical structure of MK-8189

GC69471

MK-8189

Also known as 2-methyl-6-[[(1S,2S)-2-(5-methyl-2-pyridinyl)cyclopropyl]methoxy]-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrimidin-4-amine

MK-8189 is an orally effective selective PDE10A inhibitor with a Ki value of 29 pM· MK-8189 can be used for research on schizophrenia

ChemicalCAS1424371-93-6MW382.48FormulaC19H22N6OS
CAS number
1424371-93-6
Molecular weight
382.48
Formula
C19H22N6OS
Solubility
DMSO ： 125 mg/mL (326·81 mM; Need ultrasonic)
InChIKey
WQKPZDLZRFTMTI-CABCVRRESA-N
Catalogue number
GC69471
Brand
GLPBIO
Computed properties PubChem CID 71271414 · XLogP 3.1 · TPSA 114 Ų · H-bond donors 1
XLogP
3.1
TPSA
114 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
27

SMILES CC1=CN=C(C=C1)[C@H]2C[C@@H]2COC3=NC(=NC(=C3)NCC4=NN=C(S4)C)C

Computed descriptors from PubChem (CID 71271414), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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