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Chemical structure of MK-8617

GC19251

MK-8617

Also known as N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2

ChemicalCAS1187990-87-9MW443.45FormulaC24H21N5O4
CAS number
1187990-87-9
Molecular weight
443.45
Formula
C24H21N5O4
Solubility
DMSO ： 6 mg/mL (13·53 mM)
InChIKey
WXLPERVDMILVIF-UHFFFAOYSA-N
Catalogue number
GC19251
Brand
GLPBIO
Computed properties PubChem CID 44230662 · XLogP 2.4 · TPSA 115 Ų · H-bond donors 2
XLogP
2.4
TPSA
115 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4

Computed descriptors from PubChem (CID 44230662), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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