GC70656
MK-8153
Also known as 8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(4-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one
MK-8153 is a potent, selective and orally active inhibitor of renal outer medullary potassium channel (ROMK), with IC50s of 5 nM, 34 μM for ROMK electrophysiology (EP) and hERG EP, respectively
ChemicalCAS1548286-45-8MW440.49FormulaC24H28N2O6
- CAS number
- 1548286-45-8
- Molecular weight
- 440.49
- Formula
- C24H28N2O6
- InChIKey
- KDAIMYGCILCZSH-FQEVSTJZSA-N
- Catalogue number
- GC70656
- Brand
- GLPBIO
Computed properties PubChem CID 72950074 · XLogP 0.8 · TPSA 96.4 Ų · H-bond donors 1
- XLogP
- 0.8
- TPSA
- 96.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 32
SMILES CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=C(C(=O)OC5)C)O
Computed descriptors from PubChem (CID 72950074), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il