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Chemical structure of KRAS inhibitor-3

GC69341

KRAS inhibitor-3

Also known as 2-[4-(2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol

KRAS inhibitor-3 is a KRAS inhibitor· It binds with high affinity to both wild-type and oncogenic KRAS mutants (KD: 0·28 μM for KRAS WT, 0·63 μM for KRAS G12C, 0·37 μM for KRAS G12D, and 0·74 μM for KRAS Q61H)· Additionally, it disrupts the interaction between KRAS and Raf

ChemicalCAS900897-56-5MW413.51FormulaC25H27N5O
CAS number
900897-56-5
Molecular weight
413.51
Formula
C25H27N5O
Solubility
DMSO ： 50 mg/mL (120·92 mM; Need ultrasonic)
InChIKey
MTHOJIJARWDIJS-UHFFFAOYSA-N
Catalogue number
GC69341
Brand
GLPBIO
Computed properties PubChem CID 4903596 · XLogP 3.6 · TPSA 56.9 Ų · H-bond donors 1
XLogP
3.6
TPSA
56.9 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
31

SMILES CC1=NN2C(=CC(=NC2=C1C3=CC=CC=C3)C4=CC=CC=C4)N5CCN(CC5)CCO

Computed descriptors from PubChem (CID 4903596), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.