GC60969
KRAS inhibitor-9
Also known as 4-(1,3-benzothiazol-2-ylsulfanyl)-3-chloroaniline
KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS· KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity· KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis· KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells
ChemicalCAS300809-71-6MW292.81FormulaC13H9ClN2S2
- CAS number
- 300809-71-6
- Molecular weight
- 292.81
- Formula
- C13H9ClN2S2
- Solubility
- DMSO： 250 mg/mL (853·80 mM)
- InChIKey
- DTSNLMOLTVGCGZ-UHFFFAOYSA-N
- Catalogue number
- GC60969
- Brand
- GLPBIO
Computed properties PubChem CID 667738 · XLogP 4.7 · TPSA 92.5 Ų · H-bond donors 1
- XLogP
- 4.7
- TPSA
- 92.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 18
SMILES C1=CC=C2C(=C1)N=C(S2)SC3=C(C=C(C=C3)N)Cl
Computed descriptors from PubChem (CID 667738), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il