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Chemical structure of JAK2/FLT3-IN-1

GC69305

JAK2/FLT3-IN-1

Also known as 2-[[1-[2-fluoro-4-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]piperidin-4-yl]-methylamino]ethanol

JAK2/FLT3-IN-1 is an orally effective dual JAK2/FLT3 inhibitor with IC50 values of 0·7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3 respectively· It has anti-cancer activity

ChemicalCAS2387765-27-5MW467.58FormulaC25H34FN7O
CAS number
2387765-27-5
Molecular weight
467.58
Formula
C25H34FN7O
Solubility
DMSO ： 20·83 mg/mL (44·55 mM; ultrasonic and warming and heat to 60°C)
InChIKey
CVLXNRIQVFIVGY-UHFFFAOYSA-N
Catalogue number
GC69305
Brand
GLPBIO
Computed properties PubChem CID 139600335 · XLogP 3.2 · TPSA 82.3 Ų · H-bond donors 2
XLogP
3.2
TPSA
82.3 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
34

SMILES CC1=CN=C(N=C1C2=CN(N=C2)C(C)C)NC3=CC(=C(C=C3)N4CCC(CC4)N(C)CCO)F

Computed descriptors from PubChem (CID 139600335), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.