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Chemical structure of JAK2-IN-7

GC62500

JAK2-IN-7

Also known as (E)-4-(dimethylamino)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-en-1-one

JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11·7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively· JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3· JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis· Antitumor activities

ChemicalCAS2593402-36-7MW459.59FormulaC26H33N7O
CAS number
2593402-36-7
Molecular weight
459.59
Formula
C26H33N7O
Solubility
DMSO ： 250 mg/mL (543·96 mM; Need ultrasonic)
InChIKey
SURRDPSGERGIIM-VOTSOKGWSA-N
Catalogue number
GC62500
Brand
GLPBIO
Computed properties PubChem CID 155925850 · XLogP 2.7 · TPSA 79.2 Ų · H-bond donors 1
XLogP
2.7
TPSA
79.2 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
34

SMILES CC1=CN=C(N=C1C2=CN(N=C2)C(C)C)NC3=CC4=C(CN(CC4)C(=O)/C=C/CN(C)C)C=C3

Computed descriptors from PubChem (CID 155925850), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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