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Chemical structure of JAK2 inhibitor 13 - Sulfonamide 13

GB40245

JAK2 inhibitor 13 - Sulfonamide 13

Also known as 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide

Potent and selective Janus Kinase 2 (JAK2) inhibitor; inhibits the activity of both the wild-type JAK2 and the V617F mutant (IC50 = 78 and 206 nM, respectively), with >35-fold selectivity versus JAK3 (IC50 = 2·93 µM)

ChemicalCAS1110502-30-1MW344.43FormulaC17H20N4O2S
CAS number
1110502-30-1
Molecular weight
344.43
Formula
C17H20N4O2S
InChIKey
KFJCXIOVAGJCKB-UHFFFAOYSA-N
Catalogue number
GB40245
Brand
GLPBIO
Computed properties PubChem CID 24963047 · XLogP 2.8 · TPSA 109 Ų · H-bond donors 3
XLogP
2.8
TPSA
109 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
24

SMILES CC(C)(C)NS(=O)(=O)C1=CC=C(C=C1)C2=CC3=C(C=C2)NN=C3N

Computed descriptors from PubChem (CID 24963047), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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