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Chemical structure of HIF-2α-IN-8

GC69225

HIF-2α-IN-8

Also known as (2S)-1'-chloro-8-(difluoromethoxy)-8',8'-difluoro-6-(trifluoromethyl)spiro[3H-imidazo[1,2-a]pyridine-2,5'-6,7-dihydroisoquinoline]

HIF-2α-IN-8 is an effective orally active inhibitor of HIF2α with IC50 values of 9, 37, and 246 nM for HIF2α SPA, HIF2α iScript, and HIF2α HRE RGA respectively· It has anti-tumor activity

ChemicalCAS2734922-78-0MW441.73FormulaC17H11ClF7N3O
CAS number
2734922-78-0
Molecular weight
441.73
Formula
C17H11ClF7N3O
Solubility
DMSO ： 250 mg/mL (565·96 mM; Need ultrasonic)
InChIKey
OARXSQSRBRVMQA-OAHLLOKOSA-N
Catalogue number
GC69225
Brand
GLPBIO
Computed properties PubChem CID 163827431 · XLogP 4 · TPSA 37.7 Ų · H-bond donors 0
XLogP
4
TPSA
37.7 Ų
H-bond donors
0
H-bond acceptors
10
Rotatable bonds
2
Heavy atoms
29

SMILES C1CC(C2=C([C@]13CN4C=C(C=C(C4=N3)OC(F)F)C(F)(F)F)C=CN=C2Cl)(F)F

Computed descriptors from PubChem (CID 163827431), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.