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Chemical structure of HIF-2α-IN-2

GC62584

HIF-2α-IN-2

Also known as 3-fluoro-5-[(2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl)oxy]benzonitrile

HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA)

ChemicalCAS1672666-82-8MW365.35FormulaC17H13F2NO4S
CAS number
1672666-82-8
Molecular weight
365.35
Formula
C17H13F2NO4S
Solubility
DMSO ： 100 mg/mL (273·71 mM; Need ultrasonic)
InChIKey
GTHLUQQEKIJSME-UHFFFAOYSA-N
Catalogue number
GC62584
Brand
GLPBIO
Computed properties PubChem CID 117947105 · XLogP 2.1 · TPSA 95.8 Ų · H-bond donors 1
XLogP
2.1
TPSA
95.8 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
25

SMILES CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)O

Computed descriptors from PubChem (CID 117947105), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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