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Chemical structure of E3 ligase Ligand 23

GC69036

E3 ligase Ligand 23

Also known as 4-(benzylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

E3 ligase Ligand 23 (compound 17-6) is a cereblon binder used to degrade Ikaros or Aiolos through the ubiquitin-proteasome pathway

ChemicalCAS444287-56-3MW363.37FormulaC20H17N3O4
CAS number
444287-56-3
Molecular weight
363.37
Formula
C20H17N3O4
Solubility
DMSO ： 100 mg/mL (275·20 mM; ultrasonic and warming and heat to 60°C)
InChIKey
JBYQCGLMICPOSQ-UHFFFAOYSA-N
Catalogue number
GC69036
Brand
GLPBIO
Computed properties PubChem CID 9947122 · XLogP 2.4 · TPSA 95.6 Ų · H-bond donors 2
XLogP
2.4
TPSA
95.6 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
27

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=CC=CC=C4

Computed descriptors from PubChem (CID 9947122), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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